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STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from childhood cancer patients positively correlates with SRY-Box transcription factor 9 (SOX9) expression in Sertoli cells, which in turn negatively corr

Many bacteria can interfere with how antibodies bind to their surfaces. This bacterial antibody targeting makes it challenging to predict the immunological function of bacteria-associated antibodies. The M and M-like proteins of group A streptococci (GAS) exhibit IgGFc-binding regions, which they use to reverse IgG binding orientation depending on the host environment. Unraveling the mechanism beh

Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recr

Heart failure (HF) is a leading cause of death in both men and women. However, risk factors seem to differ for men and women and significant gaps in sex-specific knowledge exist. Mitochondria are critical for cardiomyocytes and in this study, we investigated the role of baseline mitochondrial DNA copy number (mtDNA-CN) in HF incidence in middle-aged women and its possible role in the association b

In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix prot

Popular Abstract in Swedish Malmö erbjuder speciellt goda möjligheter till epidemiologiska studier, därför att all sjukhusbunden vård erbjuds av ett enda sjukhus som dessutom i stort sett endast täcker Malmös egna behov. Därtill kommer att nu avlidne professor Folke Linell redan under 1950-talet insåg den stora betydelsen för sjukvårdens kvalitet av en omfattande obduktionsverksamhet. Under periodIn the present thesis incidence, survival, mortality, cure and prognosis in invasive breast cancer in Malmö was studied over a 30 year period. Validated data from the Cancer Registry and the Cause of Death Registry were used. In the process of validation systematical biases were identified in both registers. The incidence increased over time and was strongly related to increases in diagnostic acti

Coordination of policies embracing biomass use has been called for in order to speed up progress towards the European Union renewable energy and climate change goals. Policy coordination and coherence is also required if the many complex and diverse issues constraining sustainable bioenergy development are to be addressed. To contribute to meeting such needs this doctoral thesis provides insights

The genetic basis of complete C4 deficiency in a patient with SLE was investigated. Previous studies have demonstrated that this patient has two different major histocompatibility complex (MHC) haplotypes that each contain a major deletion and a non-expressed C4 gene. In the present study, non-expression of the C4 genes was explained by the finding of two distinct C4 gene mutations. A previously d

Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development, but the relative importance of different cellular sources of PDGFB has not been established. Using Cre-lox techniques, we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also develop

Cytokines direct the differentiation of naive CD4(+) T cells into either IFN-gamma-producing T(h)1 cells or IL-4-producing T(h)2 cells. In this study, we analyzed the activation of signal transducer and activator of transcription (STAT)1, STAT3 and STAT5 (together with STAT4 and STAT6), and the expression of the recently identified suppressor of cytokine signalling (SOCS) proteins, in differentiat

A comparative analysis of the electron-hole (e-h) excitation mechanism of impurity luminescence has been performed for wide-gap oxides (WGO) and alkali halides crystals (AHC). A low quantum yield of scintillation in WGO with respect to that in AHC is connected with the high value of the average energy needed for the creation of an e-h pair in WGO. In AHC and many WGO, the width of a valence band E

Popular Abstract in Swedish Jag genomför i min avhandling en etisk analys av texter av tre samtida feministiska teologer: Chung Hyun Kyung, Sydkorea, Katie G. Cannon, USA och Mary C. Grey, Storbritannien. Genom valet av dessa tre teologer, verksamma i olika kulturella kontexter, iscensätter jag vad som kan kallas ett flerkulturellt samtal, där jag själv ingår som en part. I samtalet framträder bl In this thesis in ethics I study and analyze feminist theological texts from 1988–1997 by Katie G. Cannon, Chung Hyun Kyung and Mary C. Grey. A culturally diverse conversation is constructed, in which womanist issues, Asian women’s concerns, and feminist critique of the Western European philosophical and theological traditions are brought into dialogue with a Swedish context. The theories used are

Popular Abstract in Swedish De nu gällande trafikpolitiska principerna för kostnadsansvaret lades fast i 1988 års trafikpolitiska beslut (Regeringens proposition 1987/88:50 om trafikpolitiken inför 1990-talet). Utgångspunkten för kostnadsansvaret är trafikavgifter på samhällsekonomiska villkor med syfte att ge rätt beteendesignaler på transportområdet. Från denna utgångspunkt har kostnadsansvaret Transport is a key factor for economic growth. It has enabled both the economic scale of production and an increase in competition. No one can question this role of transportation. There is, however, a back-side to the coin: the environmental challenge. Present trends show that transportation is not compatible with sustainable development. The need to internalise the external effects from trans-po

In this paper, we present the development of a remote server that provides a user-friendly access to advanced electrocardiographic (ECG) signal processing techniques. The prototype supplies telemedicine facilities to doctors for clinical indexes remote computation to support diagnosis through the Internet. The user-friendly interface is based on the selection of the desired ECG signal processing t

let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy Article let-7 regulates radial migration of new-born neurons through positive regulation of autophagy Rebecca Petri, Karolina Pircs, Marie E Jönsson, Malin Åkerblom, Per Ludvik Brattås, Thies Klussendorf & Johan Jakobsson* Abstract During adult neurogenesis, newly formed olfactory bulb (OB)

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/embj.201695235.full_.pdf - 2026-05-08

Novisch 2017 Logoped- och Audiologiutbildningen Hej blivande logoped- eller audiologistudent! Stort grattis till att DU har blivit antagen till logoped- eller audionomprogrammet vid Lunds Universitet! Utbildningarna börjar traditionsenligt med två fartfyllda veckor tillsammans med dina nya klasskamrater och oss faddrar. Denna period (och mer därtill...) kallas för NOVISCHPERIODEN. Vi är ett gäng g

https://www.student.med.lu.se/sites/student.med.lu.se/files/rymdigtnovisch-hafte.pdf - 2026-05-08

Microsoft Word - Latest report on Africa's food crises_Sept23.doc African food crisis – the Nigerian case study Cassava farm Maize cobs Cassava tubers Maize farm P.Kormawa, I. Okike, R. Okechukwu and S. O. Akande September 2003 African Food Crisis – the Nigerian case study IITA (Nigeria)/LUND (Sweden), 2003 i TABLE OF CONTENT LIST OF TABLES..................................................

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/a14.pdf - 2026-05-08