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Sleep and pain are critical homeostatic systems that interact in a bidirectional manner. Complaints of sleep disturbance are ubiquitous among patients with chronic pain disorders, and conversely, patients with persistent insomnia symptoms commonly report suffering from chronic pain. Sleep deprivation paradigms demonstrate that partial or complete sleep loss induce hyperalgesia, possibly due to sha
Objectives: This study aimed to investigate how the use and perceived unmet need of mobility devices (MD) in people with Parkinson's disease (PD) evolve over a 3-year period. Methods: The study reports baseline assessments (n = 255) and comparisons for participants with complete data at baseline and the 3-year follow-up (n = 165). Structured questions addressed the use and perceived unmet need of
As a novel coolant, the ethylene glycol-water (50 wt.%:50 wt.%) with graphene nanoplatelets nanofluids (GnP-EGW) were prepared at four weight concentrations (0.01, 0.1 0.5 and 1.0 wt.%), and heat transfer and pressure drop characteristics in a miniature plate heat exchanger (MPHE) were investigated. All nanofluid samples were prepared and diluted by ultrasonic vibration, and their thermal conducti
Rett syndrome (RTT) is a rare neurodevelopmental disorder usually affecting females. It is associated with multiple disabilities including intellectual disability leading to a high level of dependency in all aspects of daily living including participation in physical activities. The overall aim of this thesis was to investigate physical activity behaviors by developing measures of walking, describ
Around the turn of the twentieth century, there was a growing concern within the Church of Sweden that the church was, to a too large extent, managed by the clergy alone. In an attempt to give the laity a more active and influential role in the Church of Sweden, the Brethren of the Church was established in 1918. Since it was only possible for men to become members, the organization simultaneously
Background: Whole genome sequences have allowed us to have an overview of the evolution of gene repertoires. The target of the present study, the TGFβ superfamily, contains many genes involved in vertebrate development, and provides an ideal system to explore the relationships between evolution of gene repertoires and that of developmental programs.Results: As a result of a bioinformatic survey of
Heart-hand syndrome (HHS) is a clinically and genetically heterogeneous disorder characterized by the co-occurrence of a congenital cardiac disease and an upper limb malformation. This study revealed the clinical and epidemiological features of HHS in China. The study was based on patients with congenital upper limb malformation treated in Beijing Ji Shui Tan hospital from October 1st, 2013 to Oct
The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here, we report an extensive analysis of the M. exilis genome to address this question. Unexpe
We report on the measurement of the size of the particle-emitting source from two-baryon correlations with ALICE in high-multiplicity pp collisions at s=13 TeV. The source radius is studied with low relative momentum p–p, p‾–p‾, p–Λ, and p‾–Λ‾ pairs as a function of the pair transverse mass mT considering for the first time in a quantitative way the effect of strong resonance decays. After correct
The transport of neutrons in long beamlines at spallation neutron sources presents a unique challenge for Monte-Carlo transport calculations. This is due to the need to accurately model the deep-penetration of high-energy neutrons through meters of thick dense shields close to the source and at the same time to model the transport of low- energy neutrons across distances up to around 150 m in leng
We analyze the size evolution of pebbles accreted into the gaseous envelope of a protoplanet growing in a protoplanetary disk, taking into account collisions driven by the relative sedimentation speed as well as the convective gas motion. Using a simple estimate of the convective gas speed based on the pebble accretion luminosity, we find that the speed of the convective gas is higher than the sed
We measured absolute cross sections for neutron transfer channels populated in the Rb94+Pb208 binary reaction. Cross sections have been extracted identifying directly the lead isotopes with the high efficiency MINIBALL γ-ray array coupled to a particle detector combined with a radioactive Rb94 beam delivered at Elab=6.2 MeV/nucleon by the HIE-ISOLDE facility. We observed sizable cross sections in
Twenty-two female psychiatric outpatients with experiences of childhood sexual abuse took part in a two-year group therapy. All Completed therapy. At the end of therapy the women's psychiatric symptoms were reduced and their social interaction and adjustment were improved. They evaluated relationships to their children, partners and friends to be improved.
The use of hyperbaric oxygen therapy (HBO) in the treatment of certain types of diabetic foot ulcers (DFU) has been the topic of much debate and disagreement over the last several decades. In this review, the evidence for its use is presented and discussed by two experts in DFU management. Whereas some randomized controlled trials suggest that HBO may speed the healing of certain ischaemic or neur
Introduction: The benefits of simulation-based medical training are well described. The most effective way to plant and scale simulation training in rural locations remains undescribed. We sought to plant simulation training programmes for anaesthesia emergencies in two rural Indian hospitals. Methods: Two Indian consultant anaesthetists without experience in medical simulation underwent a 3-day c
Objective. Patients with ANCA-associated vasculitides (AAV) exhibit higher rates of malignancy than the general population. We assessed whether the cancer risk is increased in a well-characterized population-based cohort of AAV in southern Sweden, followed for a median time of 8 years. Methods. With case record review, the outcomes and malignancy development in a cohort of 195 patients with AAV [g
Objective: To study if comatose cardiac arrest patients can be assessed with a reduced number of EEG electrodes. Methods: 110 routine EEGs from 67 consecutive patients, including both hypothermic and normothermic EEGs were retrospectively assessed by three blinded EEG-experts using two different electrode montages. A standard 19-electrode-montage was compared to the reduced version of the same EEG
