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Herpes simplex virus type 1 (HSV-1) delivers its genome into the host nucleus via docking of the viral capsid at the nuclear pore complex (NPC), a process mediated by the capsid vertex-specific complex (CVSC), composed of UL17, UL25, and UL36. While prior in vivo studies have implicated UL25 and UL36 in NPC interactions, their interpretation is complicated by indirect effects from viral traffickin
INTRODUCTION: We evaluated differences in p-tau levels between Alzheimer's disease (AD), a condition with brain-specific changes in p-tau, and amyotrophic lateral sclerosis (ALS), a condition associated with increases in peripheral p-tau levels. METHODS: Cerebrospinal fluid and plasma from 668 participants were analyzed using immunoassays specific for the low-molecular-weight (LMW) tau isoforms pr
In the past years, anti-genderism has become a growing force in politics. The word ‘gender’ has become an empty signifier to attack queer and feminist agendas, sexual and reproductive rights but also gender studies scholars and courses. Social media, particularly Twitter stands out in the spread of anti-genderism despite its 280-character limit. Using political netnography and feminist critical di
Cannabisaktivism, en del av Argentinas bredare tradition av sociala rörelser, har utvecklats till ett dynamiskt fält för motstånd och påverkansarbete – särskilt när det gäller medicinsk cannabis, som hamnade i fokus år 2015. Faktum är att min avhandling tog sin startpunkt i och med att jag etablerade kontakt med Mama Cultiva, en sammanslutning av mödrar, som spelade en aktiv roll i skapandet av enCannabis activism, which is embedded in Argentina’s broader tradition of social movements, has become a dynamic field of resistance and advocacy, particularly regarding medicinal cannabis, which came into focus in 2015. Indeed, the research for my thesis began by establishing contact with Mama Cultiva, a mothers’ organisation that played an active role in the creation of a new cannabis law and dra
Precise knowledge of the temperature during cutting processes is of high interest as the temperature of a cutting tool dictates the performance, and for the workpiece it controls the quality and integrity of the generated surface. For the first time, in this study, a novel technique has been developed utilizing phosphor thermometry for 2D surface temperature measurement of a cutting tool in metal
Background/Objectives: There is still no consensus as to whether patients with upfront resectable synchronous colorectal liver metastases (sCRLM) should receive neoadjuvant treatment prior to liver surgery. Two randomized controlled trials have assessed the role of peri-operative chemotherapy in sCRLM; neither have shown a survival benefit in the neoadjuvant group. The aim of this population-based
Restoring cultivated peatlands has become a silver bullet in climate change mitigation policies globally due to peatlands’ potentials to sequester carbon. In Denmark, carbon is the focal point for such interventions but simultaneously conspicuous by its absence in local restoration efforts. Scientific abstractions render carbon visible through maps and models presenting soil’s carbon content, emis
Introduction: Malaria remains a persistent challenge in global health, disproportionately affecting populations in endemic regions (eg, sub-Saharan Africa). Despite decades of international collaborative efforts, malaria continues to claim hundreds of thousands of lives each year, with young children and pregnant women enduring the heaviest burden. This concise review aimed to provide an up-to-dat
Portal hypertension (PH) is a major complication of chronic liver disease, often leading to serious clinical consequences such as variceal bleeding, ascites, and splenomegaly. The current gold standard for PH diagnosis, namely, hepatic venous pressure gradient measurement, is invasive and not widely available. Transient elastography has emerged as a non-invasive alternative for assessing liver sti
The turn of the twentieth century was a period of rapid decline in infant- and child mortality and a time of industrialization and urbanization in Sweden. It was also a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions, infant care, and possibly nutrition.
The turn of the twentieth century was a period of rapid decline in infant- and child mortality and a time of industrialization and urbanization in Sweden. It was also a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions, infant care, and possibly nutrition.
Background: Serially interconnected microfluidic devices enable advanced applications such as multi-step chemical processing and multi-organ-on-chip systems. However, managing these systems presents challenges due to interdependent fluid dynamics in their connecting channels, where even minor disturbances can propagate throughout the network, affecting overall system performance. Methods: This stu
Background: Antithrombotic treatment might affect bleeding symptoms, identification of bleeding source and treatment for patients with acute gastrointestinal bleeding. This study aims to investigate possible differences in initial bleeding symptoms, identified bleeding site and treatment of patients with or without antithrombotic medication admitted for gastrointestinal bleeding. Methods: All cons
This study examines how two instructional conditions - explicit and implicit narrative instruction - were implemented in Swedish preschools, drawing on principles from implementation science. Data from 21 preschool departments—including video recordings, teacher interviews, and survey data - were analyzed using a mixed-methods approach. The implicit approach (HINT), focusing on shared reading and
The feasibility of South Africa's just energy transition, as dictated by the speed of phasing out coal and scaling up renewables, will rest on a range of techno-economic, socio-political, and socio-technical factors. Interactions between these dimensions of the transition carry significant implications for energy justice. In response, this paper proposes the Just Transition Feasibility Framework (
Policing roles require specific work-related characteristics (WRCs) critical for effective performance. This study identifies key WRCs for various roles within the Swedish Police—patrol officers, criminal investigators, Special Weapons and Tactics (SWAT) Teams, police chiefs, and negotiators—by analyzing data from 425 active-duty officers (30% response rate). We use the Occupational Information Ne
Mot bakgrund av tilltagande ekologiska kriser, växande socioekonomiska ojämlikheter och ett klimat i förändring har behovet av att omvandla jordbrukssystem mot hållbarhet och rättvisa blivit alltmer akut. En sådan omvandling hindras emellertid ofta av djuprotade strukturer och institutionella arrangemang som gynnar snävt definierade föreställningar om produktivitet och marknadseffektivitet. DärigeAmid escalating ecological crises, widening socio-economic inequalities, and intensifying climate change, the imperative to transform agricultural systems towards sustainability and equity has become increasingly urgent. Yet suchtransformation is often hindered by entrenched institutional and structural arrangements that privilege narrowly defined notions of productivity and market efficiency, the
Purpose: The sugar industry is always pressured to be suitable and enhance its operational effectiveness. Digital Twin (DT) has the potential to transform this industry. However, the lack of industry-specific Key Performance Indicator (KPI) frameworks makes it challenging to implement them. This study provides a hierarchical KPI model for DT adoption in the sugar sector, interconnecting the United
