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Background: Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been linked. Method: Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized to postnatal enteral AA/DHA supplementation or standard care (contro
We previously showed that quinacrine (QC), a small molecule antimalarial agent, also presented anticancer activity in breast cancer cells through activation of p53, p21, and inhibition of topoisomerase activity. Here we have systematically studied the detailed cell death mechanism of this drug using three colon cancer cell lines (HCT-116 parental, isogenic HCT-116 p53-/-, and HCT-116 p21-/- sublin
The complex orography of the Tibetan plateau (TP) and the scarcity and uneven spatial distribution of meteorological stations present significant challenges in accurately estimating meteorological variables for hydrological simulations. This study aims to enhance the accuracy of daily precipitation and temperature interpolation for hydrological simulations in the Lhasa River Basin (LRB), particula
Recently, work conducted by the European Commission’s Joint Research Centre demonstrated that Ireland had the highest prevalence of loneliness of all European countries. Given the range of adverse physical and psychological consequences associated with loneliness, it is vital to ask why Ireland is experiencing such high prevalence. Here, we discuss potential contributing factors, including: Irelan
Agonistic CD40 antibodies activate dendritic cells and can expand and activate tumor-specific T cells. Our purpose was to assess the CD40 agonistic antibody ADC-1013 in the clinical setting including intratumoral administration since preclinical studies have indicated that intratumoral is better than intravenous administration. A Phase I, open label, multicenter study was conducted in patients wit
We explore how the Resilient Urban Food Systems (RUFS) project applied a theory of change approach to raise awareness of the importance of smallholder farmers and to bring them into decision making processes, as key players working towards a sustainable and resilient food system in Kasese Municipality and Mbale City in Uganda. Critical inputs from using a theory of change approach included: consta
Identifying potential moisture damage is crucial for maintenance practices and assurance of well-being of occupants. However, due to limited information availability and standardization, assessing damage prevalence on the building stock scale remains understudied. By combining investigation records and building databases, this study leverages data analytic techniques and machine learning modeling
Today's petrochemical industry relies on fossil hydrocarbons, not only for energy purposes but also as feedstock. This use of fossil materials is being challenged by the European Union's target to achieve climate neutrality by 2050. The most affected region in Europe is the cross-border region between Antwerp, Rotterdam and the Rhine-Ruhr area in western Germany, an interconnected petrochemical me
Plastic contamination has become a major environmental concern and impacts human health, and yet this is still a topic that remains largely understudied. Effects of macro- and microplastics on soil physical, chemical, and biological properties, including soil biota, are considered adverse for soils. Due to their small size and porous surface, microplastics can also be a new environmental concern b
Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e. amyloid-β plaques and neurofibrillary tangles comprised of hyperphosphorylated tau. Depending on the type and location of trauma,
INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear. METHOD: Longitudinal demographics, T1-weighted magnetic resonance imaging (MRI), and cognitive scores of 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]-negative
At the core of this artistic research project is the idea that composing music can entail more than structuring sonic material; it may involve constructing the very space in which musical thoughts take shape. This space, the composable, is understood not as a fixed, pre-existing framework but as a space in flux—shaped by instruments, devices, spatial configurations, and performative gestures—where
This paper investigates the acquisition of rhetorical questions (RhQs) inmonolingual children acquiring Italian, comparing the comprehension andproduction of RhQs based on their optional lexical, morphosyntactic, andprosodic cues. We show that 6-to-9-year-old children are in the process ofacquiring the use of optional lexical and morphosyntactic markers in produc-tion (e.g. discourse particles, in
PURPOSE: Posterior fossa tumour (PFT) surgery carries a risk of mutism or severely reduced speech. As for higher-cognitive language functions, word-finding difficulties have been reported, but no study has compared pre- and postoperative word-finding speeds to identify impairment caused by surgery. The current study investigated changes in word-finding ability associated with PFT surgery and exami
Industry 4.0 concepts have recently significantly supported transparency and reliability in every industrial sector. Organizations must adapt their traditional paradigms and approaches to align with market demands. Hence, developing a framework that can change these conventional approaches with fresh ideas is essential. The Industry 4.0 (I4.0) readiness model presents a creative concept that holds
This presentation focuses on a project at an early stage of development. The aim of the practice lab project is twofold: (i) to strengthen the competence among students in higher music education with regards to the topic of practice, and (ii) contribute to research on musical practice and skill acquisition. The project is conducted at Malmö Academy of Music (Lund university). Students take part in
Maladaptive daydreaming is a distinct syndrome in which themain symptom is excessive vivid fantasising that causesclinically significant distress and functional impairment inacademic, vocational and social domains. Unlike normaldaydreaming, maladaptive daydreaming is persistent, compulsiveand detrimental to one’s life. It involves detachmentfrom reality in favour of intense emotional engagement wi
This article examines the expanding role of Artificial Intelligence (AI) in healthcare and associated human rights concerns, including whether new EU legislation takes all relevant human rights concerns into account. AI presents promising ways to fulfil the right to health through improving diagnostics, treatments, and resource allocation, but its use also comes with risks concerning privacy, bias
The effect of β-glucan was tested on microstructure, sensory-specific satiation, subsequent food intake, and in vitro lipid digestion. A high internal phase emulsion was prepared with 75 % milk fat and 25 % whey protein water dispersion, and added as the lipid source to milkshake matrices. Two milkshake variants, one with 1 % β-glucan and the other without fibre, were produced and characterised by
