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Athletes constantly report experiences of momentum during athletic contests, and they consider momentum as being an important factor for the outcome of a competition. However, researchers trying to capture momentum with quantitative methods see themselves confronted with inconclusive results. To explain this gap between athletes’ belief and results from quantitative data, it is hypothesised that m
End-tidal PCO2 (PET CO2 ) has been used to estimate arterial pressure CO2 (Pa CO2 ). However, the influence of blood temperature on the Pa CO2 has not been taken into account. Moreover, there is no equation validated to predict Pa CO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperature-corrected Pa CO2 values during exercise in normoxia and severe acute hypoxi
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or by induction of epigenetic marks de novo in each generation. To distinguish between these possibilities we measured epigenetic marks over four generati
Popular Abstract in Swedish Många av dagens stora folksjukdomar, såsom cancer, diabetes och hjärt-kärlsjukdomar, kopplas i allt högre grad samman med olika riskfaktorer som beror på förändringar i arvsmassan. Dessa nya kopplingar har möjliggjorts tack vare den extrema utveckling av genetiska mätmetoder som har skett under de senaste 15 åren. Med de nya metoderna kan förekomsten och aktiviteten hosThis thesis deals with methods for extracting robust and relevant information from high-dimensional data sets, and statistically guided visualization methods for representing the data in an informative and easily accessible way. High-dimensional data sets are becoming increasingly prevalent in many different scientific disciplines. In this thesis, we focus particularly on so called "omics" data. T
Popular Abstract in Swedish Hematopoes är bildandet av blodceller. Blodbildningen har sin utgångspunkt i benmärgen i stamceller vilka ger upphov till i huvudsak åtta typer av blodceller med var sina specifika uppgifter. De röda blodkropparna transporterar syre från lungorna ut i hela kroppen,blodplättar har sin främsta funktion i att initiera stopp av en blödning,granulocyter och makrofager äter uA common feature in myeloid leukemia is suppression of normal hematopoiesis, leading to infections, bleeding and anemia. It has been suggested for a long time that leukemic cells possess a growth-advantage by overproducing an inhibitor - a leukamia associated inhibitor. Such an inhibitor has been characterized in leukemic cells as well as subpopulations of normal bone marrow and blood cells, sugge
Arsenic, an established carcinogen and toxicant, occurs in drinking water and food and affects millions of people worldwide. Arsenic appears to interfere with gene expression through epigenetic processes, such as DNA methylation and post-translational histone modifications. We investigated the effects of arsenic on histone residues in vivo as well as in vitro. Analysis of H3K9Ac and H3K9me3 in CD4
AbstractOrganizational routines that are critical to learning, flexibility, and adaptation explain the behavior of the business organization. When organizational routines cross the boundary of the organization, variability and stability are affected. This study emphasizes organizational routines committed in specific outsourcing or insourcing situations to clarify the dynamics of organizational roOrganizational routines that are critical to learning, flexibility, and adaptation explain the behaviour of the business organization. When organizational routines cross the boundary of the organization, variability and stability are affected. This study emphasizes organizational routines committed in specific outsourcing or insourcing situations to clarify the dynamics of organizational routines
For metallic glasses, it is of vital importance to understand the glass formation properties and to be able to predict the crystallization process in the supercooled liquid. In the present work, we model the process of nucleation and growth using a combination of classical nucleation and phase-field theory. A diffusion coupled phase-field model is used to evaluate the work of formation and the gro
The ambition to integrate disaster risk information from multiple stakeholders exists at different scales in any country and serve to control the risk of losses within companies, organizations and countries as a whole. Against the backdrop of extensive deliberations with risk management professionals in Sweden, this paper is based on an interdisciplinary scoping study of literature aimed to enhanc
alpha 1-Microglobulin is an immunosuppressive plasma protein synthesized by the liver. The isolated protein is yellow-brown, but the hypothetical chromophore has not yet been identified. In this work, it is shown that a human liver cell line, HepG2, grown in a completely synthetic and serum-free medium, secretes alpha 1-microglobulin which is also yellow-brown, suggesting a de novo synthesis of th
Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated the expression of MARCO in relation to other macrophage markers and immune pathways in a non-small cel
A review of a two-hander Romeo and Juliet plus a Shakespeare mash-up, both in Lund.
In a spatial simulation we show that formation of a stable, narrow hybrid zone requires no selection, only that individuals can recognize their own population type since this is a prerequisite for assortative mating. The European crow occurs in two species/subspecies that meet in a long hybrid zone, the black carrion crow Corvus corone and the grey and black hooded crow C. cornix. In a previous st
Objective: This study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages. Methods: Prospective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and long
BACKGROUND: Long-term cognitive problems are common among elderly patients after surgery, and it has been suggested that inhalation anaesthetics play a role in the development of dementia. This study aims to investigate the hypothesis that patients with dementia have been more exposed to surgery and inhalational anaesthetics than individuals without dementia.METHODS: Using 457 cases from a dementi
The agents driving the divergence and speciation of free-living microbial populations are still largely unknown. We investigated the dinoflagellate morphospecies Scrippsiella hangoei and Peridinium aciculiferum, which abound in the Baltic Sea and in northern temperate lakes, respectively. Electron microscopy analyses showed significant interspecific differences in the external cellular morphology,
To mimic the two-signal requirements for T cell activation mediated by ligands, we exposed the superantigens SEA or SEE (signal 1) to T cells incubated with HLA-DR/LFA-3 or HLA-DR/137-1-CHO transfected cells (signal 2). LFA-3 costimulation was able to induce T cell proliferation as well as IFN-gamma and IL-4 production at similar levels as in cells induced by B7-1. Analysis of the CD28RE of the IL
Abstract in German Hintergrund: Es wurde in einer populationsbasierten Fallkontrollstudie die Assoziation von Antikörpern auf Streptokokkus pyogenes Antigene mit der Entwicklung eines abdomionellen Aortenaneurysma (BAA) untersucht. Patienten und Methoden: 42 Patienten, bei denen ein BAA durch Screnning entdeckt wurde, wurden mit 100 alters- und geschlechtsgleichen Kontrollpatienten mit normaler AoBackground: In a population -based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached
PURPOSE: To investigate assumed benefits of heparin coated cardiopulmonary bypass systems from standard non-coated CBP systems in unstable angina patients with preoperative heparinisation. STUDY DESIGN: Coagulation, complement, cytokine and Sonoclot parameters, were analyzed before total heparinisation prior to surgery, during cardiopulmonary bypass, after protamine to 48 hours after surgery. MATE
The planetary changes associated with the Anthropocene, including climate change and extinction of species, pose severe threats to civilization, humanity, and the natural world as we know it. They also pose special challenges to the human imagination. To meet these challenges, climate change communicators use narratives. Nonfiction books intended for a general audience employ two radically differeThe planetary changes associated with the Anthropocene, including climate change and extinction of species, pose severe threats to civilization, humanity, and the natural world as we know it. They also pose special challenges to the human imagination. To meet these challenges, climate change communicators use narratives. Nonfiction books intended for a general audience employ two radically differe
